Starring: Owen Wilson, George Lopez and Lee Pace Director: Directed by Tom Dey Marmaduke (voice of Wilson), the world's most lovable Great Dane, leaps from comic strip fame to big screen stardom. The super-sized dog who never fit in finally finds a place where it's okay to stand out. Now living large in Orange County, California, Marmaduke helps his family make the big transition from the Midwest to The O.C. But he also discovers that fitting in with his new four-legged friends isn't always easy for a 200-pound teenage dog. Lucky for Marmaduke, he always has his best pal, Carlos (voice of Lopez), a Russian Blue Cat, watching his back.