Life couldn't get any worse for ad executive Nick Beam (Robbins) who believes his wife is having an affair with his boss. On the verge of a nervous breakdown, he’s robbed at gunpoint by a fast-talking thief named T. Paul (Lawrence). With nothing to lose, Nick turns the tables on his mugger, taking T. Paul hostage and embarking on a wild road trip. An unlikely friendship gradually unfolds between this offbeat pair in a madcap comedy of hold-ups, high-speed chases, mistaken identities and revenge.